PrashantKumar Khirsariya, Ph.D., M.Sc.

2018

• Preparation of 3,4-Substituted-5-Aminopyrazoles and 4 Substituted-2-Aminothiazoles

  HAVEL Štěpán KHIRSARIYA PrashantKumar AKAVARAM Naresh PARUCH Kamil CARBAIN Benoit Jean-Pierre

  Article in Periodical

  The Journal of Organic Chemistry, year: 2018, volume: roč. 83, edition: č. 24, DOI

• Selective CHK1 inhibitor MU380 exhibits single-agent activity against chronic lymphocytic leukemia cells with TP53 mutations

  BOUDNÝ Miroslav ZEMANOVÁ Jana KHIRSARIYA PrashantKumar BORSKÝ Marek VERNER Jan ČERNÁ Jana MRÁZ Marek OLTOVÁ Alexandra JAŠKOVÁ Zuzana ŠPUNAROVÁ Michaela ŠEDA Václav BRYCHTOVÁ Yvona MAYER Jiří PARUCH Kamil TRBUŠEK Martin

  Conference abstract

  Year: 2018, type: Conference abstract

2017

• Diastereoselective Flexible Synthesis of Carbocyclic C Nucleosides

  MAIER Lukáš KHIRSARIYA PrashantKumar HYLSE Ondřej ADLA Santosh Kumar ČERNOVÁ Lenka POLJAK Michal KRAJČOVIČOVÁ Soňa WEIS Erik DRÁPELA Stanislav SOUČEK Karel PARUCH Kamil

  Article in Periodical

  The Journal of Organic Chemistry, year: 2017, volume: 82, edition: 7, DOI

• Flow cytometric analysis of nucleoside transporters activity

  DRÁPELA Stanislav FEDR Radek KHIRSARIYA PrashantKumar PARUCH Kamil SOUČEK Karel

  Conference abstract

  Year: 2017, type: Conference abstract

• Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells

  HERŮDKOVÁ Jarmila PARUCH Kamil KHIRSARIYA PrashantKumar SOUČEK Karel KRKOŠKA Martin VONDÁLOVÁ BLANÁŘOVÁ Olga SOVA Petr KOZUBÍK Alois HYRŠLOVÁ VACULOVÁ Alena

  Article in Periodical

  Neoplasia, year: 2017, volume: 19, edition: 10, DOI

• Structural Basis of the Interaction of Cyclin-Dependent Kinase 2 with Roscovitine and Its Analogues Having Bioisosteric Central Heterocycles

  NEKARDOVÁ Michaela VYMĚTALOVÁ Ladislava KHIRSARIYA Prashant Kumar KOVÁČOVÁ Silvia HYLSOVÁ Michaela JORDA Radek KRYŠTOF Vladimír FANFRLÍK Jindřich HOBZA Pavel PARUCH Kamil

  Article in Periodical

  ChemPhysChem, year: 2017, volume: 18, edition: 7, DOI

• Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation

  SAMADDER Pounami SUCHÁNKOVÁ Tereza HYLSE Ondřej KHIRSARIYA PrashantKumar NIKULENKOV Fedor DRÁPELA Stanislav STRAKOVÁ Nicol VAŇHARA Petr VAŠÍČKOVÁ Kateřina KOLÁŘOVÁ Hana BINÓ Lucia BITTOVÁ Miroslava OVESNÁ Petra KOLLÁR Peter FEDR Radek EŠNER Milan JAROŠ Josef HAMPL Aleš KREJČÍ Lumír PARUCH Kamil SOUČEK Karel

  Article in Periodical

  Molecular Cancer Therapeutics, year: 2017, volume: 16, edition: 9, DOI

2016

• Development and validation of a highly sensitive LC-MS method for determination of checkpoint kinase 1 inhibitors in mouse plasma

  BITTOVÁ Miroslava KOLÁŘOVÁ Hana HYLSE Ondřej KHIRSARIYA PrashantKumar PARUCH Kamil

  Article in Proceedings

  Advances in chromatography and electrophoresis & Chiranal 2016, year: 2016

2015

• Chronic lymphocytic leukemia cells are highly susceptible to direct inhibition of checkpoint kinase

  ZEMANOVÁ Jana PARUCH Kamil KREJČÍ Lumír SOUČEK Karel HYLSE Ondřej BOUDNÝ Miroslav BORSKÝ Marek OSIČKOVÁ Jitka KHIRSARIYA PrashantKumar ŠEBEJOVÁ Ludmila NAVRKALOVÁ Veronika MALČÍKOVÁ Jitka DIVÍŠKOVÁ Eva BRYCHTOVÁ Yvona MAYER Jiří TRBUŠEK Martin

  Conference abstract

  Year: 2015, type: Conference abstract